J.Jpn. Surg. Soc.. 88(10): 1485-1493, 1987

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Original article

QUANTITATIVE STUDY OF PLATELET DEPOSITION ON EXPANDED POLYTETRAFLUOROETHYLENE GRAFTS USING ¹¹¹INDIUM-LABELED PLATELETS

The count of platelets deposited on expanded polytetrafluoroethylene grafts (2cm long, 3mm internal diameter, implanted into thoracic aortae of 59 rabbits) was measured using ¹¹¹Indium-labeled autologous platelets.
The changes due to the time courses after implantation, the effect of aspirin and the differences of the platelet deposion on the thrombus and thrombus free surface were studied.
In non-treated gafts, platelet deposition on the thrombus free surface was significantly and repeatedly decreased on the 3rd (42.3±16.6×10⁴/mm², mean±S.D.), 9th (17.7±5.3×10⁴/mm²), and 30th (6.8±3.2×10⁴mm²) days after the implantation (p＜0.05).
In treated grafts, platelet deposition on the thrombus free surface was significantly inhibited by aspirin on the 3rd day (20.5±8.4×10⁴/mm²) after implantation (p＜0.03), while significant inhibition of platelet deposition by aspirin was not noted on the 9th (13.4±3.8×10⁴/mm² and 30th (13.1±4.5×10⁴/mm²) days after the implantation.
Platelet deposition on the thrombus was not inhibited by aspirin. (3600±2400×10⁴/mm², non-treated grafts. 3500±520×10⁴/mm² treated grafts).
It is concluded that administration of aspirin is necessary immediately after implantation, and its effect is not noted at the time when the deposition of the platelet decreased, and the effect of aspirin cannot be expected in tissues where easy platelet aggregation occurs.

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