J.Jpn. Surg. Soc.. 88(10): 1466-1478, 1987

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Original article

EFFECT OF PANCREATIC JUICE DIVERSION ON GASTRIC ACID AND GUT HORMONE SECRETION

In an effort to clarify the effect of pancreatic juice diversion (PJD) on the gastric acid and gut hormone secretion, models of PJD and non-PJD were prepared in dogs with Heidenhain pouch (HP). Two types of operative procedures, pancreatico-jejunostomy with Roux-Y reconstruction as a PJD model (RY group), and pancreatico-jejuno-duodenostomy using interposed jejunum as a non-PJD model (INT group) were carried out.
The results were obtained as follows.
1. Both endocrine and exocrine function of the pancreas were preserved by either procedure.
2. Gastric acid secretion from HP after test meal ingestion was significantly increased postoperatively in RY group and was not affected in INT group.
3. Postprandial secretion of gastrin was not affected by these operative procedures in both RY and INT group. Secretion of GIP was significantly suppressed in RY group and was not changed in INT group. Secretion of enteroglucagon was significantly increased in both groups.
These results indicate that significant increase of postprandial gastric secretion as shown in RY group is conceivably based on the significant suppression of GIP secretion produced by PJD.

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