J.Jpn. Surg. Soc.. 87(11): 1426-1431, 1986

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Original article

PRODUCTION, ABSORPTION AND EXCRETION OF PHENOLS IN INTESTINAL OBSTRUCTION

In intestinal obstruction, phenols were produced in the distended loop proximal to obstruction by enteric bacteria. Clinically, in 17 cases of non-strangulated intestinal obstruction, phenols were detected in 15 cases and mean concentration of phenols was 4.2±9.7 micro g/ml (mean±1SD). In the fraction of phenols, p-cresol was detected in 15 cases and mean concentration was 3.8±7.7 and pheriol was detected in 4 cases and mean concentration was 0.5±2.6. Phenols were decreased as clinical improvement of intestinal obstruction. Enteric bacteria in enteric juice ranged from 10⁴ to 10¹⁰/ml and its change paralleled to phenols concentration. Mean urinary concentration of phenols in intestinal obstruction was increased to 297±415mg/day compared to control(less than 50mg/day). Its change also paralleled to phenols concentration in enteric juice. Closed ileal loop was made in dogs and phenols were infused in the loop. Phenols were increased in the portal vein 5 min after the infusion and in the femoral vein 60 min after the infusion. Phenols, which was thought to be toxic to the host, were proved to be produced in the distended intestine and excreted from the kidney.

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