J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 2495KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 87(11): 1391-1397, 1986

Original article

RENAL TUBULAR IMPAIRMENT IN TRAUMATIZED PATIENTS

Department of Traumatology, Osaka university Medical School, Osaka, Japan

Jun-ichiro Yokota, Toshihisa Sakamoto, Masaaki Uenishi, Masanori Shibuya, Kimiaki Hashimoto, Toshiharu Yoshioka, Tsuyoshi Sugimoto

Urinary β2-microglobulin (β2M) and N-acetyl-β-D-glucosaminidase (NAG) in addition to conventional renal parameters such as creatinine clearance (Ccr), free water clearance (CH2O) and fractional excretion of sodium (FENa) were measured in 79 traumatized patients. These patients were separated into two groups, one with shock on admission(N=36), the other without shock (N=43).
In patients with shock, CH2O, FENa and urinary excretion of β2M and NAG indicated abnormal levels correlating with impairment of Ccr, inspite of adequate urine output, on the day of trauma. Even in patients without shock, urinary β2M and/or NAG increased without impairment of urine output, Ccr, CH2O and FENa, and did not return to normal level during the following 7 days.
The results suggest a liability to damage and the delayed improvement of renal tubulus in traumatized patients.

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