J.Jpn. Surg. Soc.. 87(10): 1284-1292, 1986

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Original article

STUDIES ON HEMORRHAGIC GASTRITIS AFTER EXTENDED GASTRIC DEVASCULARIZATION USING PORTAL HYPERTENSIVE DOGS

We studied a cause of postoperative hemorrhagic gastritis in the disease of portal hypertension experimentally. Five portal hypertensive dogs, produced by our whole liver compression procedure, underwent transabdominal devascularization on one-third upper gastric portion. In the gastric cardia, mucosal blood flow and tissue oxygen tension (PTO₂) were measured by Hydrogen gas clearance method and PTO₂ sensor for 14 days after surgery. Moreover P₅₀, 2,3-DPG, pH, Hb, and blood temperature were also monitored for 14 days.
In gastric hemodynamic changes, mucosal blood flow showed a moderate reduction immediately after surgery and returned to the previous value on the 14th postoperative day, although the value of PTO₂ was dropped gradually for 14 days. Especially, postoperative changes in PTO₂ showed significant correlation with P₅₀ and 2,3-DPG. On the other hand, slight atrophic gastritis was recognized microscopically in devascularized gastric cardia.
From these results, mucosal hypoxia of the upper gastric portion may be influenced by a remarkable reduction of P₅₀ and 2,3-DPG, and it seems to easilly lead to the state of hemorrhagic gastritis.

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