J.Jpn. Surg. Soc.. 87(7): 724-736, 1986

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Original article

IMMUNOHISTOCHEMICAL STUDY OF THE LOCAL IMMUNITY IN CARCINOMA OF THE ESOPHAGUS

In order to elucidate the local immunity in esophageal carcinomas, infiltrating cells and cells containing Ig located in the lamina propria near the tumor and T cell subsets in the struma of the tumor were analysed quantitatively in 45 cases of intrathoracic esophageal carcinoma.
1) Infiltrating cells were observed in the 5mm wide lamina propria near the tumor more than in other regions. Most of them were lymphocytes and plasma cells. Infiltrating cells in the unit area (0.0056mm²) were 16.7±6.4 in the oral area,18.2±7.4 in the anal area.
2) The proportion of cells containing Ig was about 50%, 45%, and 3－5% for IgG, IgA and IgM, respectively.
3) In cases with preoperative therapy infiltrating cells and cells containing IgA were fewer than in cases without preoperative therapy.
4) In the group of well differentiated squamous cell carcinoma or in a large tumor, more than 5cm in longitudinal diameter, or where there was no lymphnode metastasis or no invasion of adventitia, many infiltrating cells and cells containing Ig were noted.
5) There were many Leu 4 positive cells (T cells) within the struma of the tumor and Leu 2a and Leu 3a positive cells mingled in various proportions.

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