J.Jpn. Surg. Soc.. 87(2): 180-188, 1986
Original article
EXPERIMENTAL STUDY ON THE PATHOGENESIS OF ACUTE ULCERATION IN OBSTRUCTIVE JAUNDICE
－WITH REFERENCE TO GASTRIC MUCOSAL BLOOD FLOW－
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The First Department of Surgery, Kobe University School of Medicine, Kobe, Japan Tomoaki Urakawa, Yoshi Nagahata, Shuji Fukuoka, Tamiki Hayashi, Takayoshi Takata, Shoji Matsui, Mitsuharu Nakamoto, Yasuhiro Hirai, Kimindo Kumagai, Yoichi Saitoh |
1. In the obstructive jaundice 2 weeks group, when subjected to water immersion restraint stress, gastric mucosal NA reached a dried up stage from the incipient stage, causing gastric mucosal impediments at the same time, showing a significant decrease of gastric mucosal PGE2. Intragastric pH was at a similar level of excessive acidity in all groups ; gastric acid is believed to be a secondary factor promoting ulceration.
2. Gastric mucosal PGE2 showed a significant decrease coinciding with the increase in ulceration index, being a possible factor of ulceration；it is also presumed to regulate gastric wall blood flow alternatively with gastric mucosal NA.
3. Pre-treatment with PGE2 prior to loading stress resulted in a decrease in gastric wall blood flow being significantly controlled. The administration of PGE2 brought about an improvement in gastric wall blood flow and a consequent increase in gastric mucosal NA, being judged effective for acute ulceration in obstructive jaundice.
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