J.Jpn. Surg. Soc.. 86(6): 717-724, 1985

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Original article

EXPERIMENTAL STUDY ON RESPIRATORY FAILURE WITH ACUTE PANCREATITIS IN DOGS

In this experimental study, we investigated pathophysiology of respiratory failure with acute pancreatitis. Pancreatitis was induced by injection of 15% Na-taurocholate 1ml/kg into the main pancreatic duct of the dogs. Experimental dogs were devided into two groups based on the value of Respiratory Index (R-Index). Group A included 9 dogs in whom respiratory failure was not recognized (R-lndex＜0.5) and Group B included 9 dogs with respiratory failure (R-lndex＜0.5). All the dogs were sacrified 12 hours after induction of pancreatitis, and histological findings were examined. Quantity of water in the lung (Qwl) was also measured by gravimetric method.
Group B showed severe hypoxia with hypocapnea, and increase of A-aDO₂, R-Index, and decrease of a/A PO₂. Qwl in Group B increased significantly comparing with Group A. In biochemical study, increase of serum lipase, triglyceride, free fatty acid, and angiotensin converting enzyme were observed in Group B. These results indicate that respiraoty failure with acute pancreatitis is due to lung edema following injury of the capillary of the lung. The role of free fatty acid liberated by lipolysis was suggested in the mechanism of pulmonary damage with acute pancreatitis.

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