J.Jpn. Surg. Soc.. 86(5): 544-554, 1985
Original article
THE EFFECTS OF HEPATIC ISCHEMIA ON SYSTEMIC BLOOD COAGULATION AND FIBRINOLYSIS IN MONGREL DOGS．
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Second Department of Surgery, Nagoya University School of Medicine, Nagoya, Japan Masahiko Shinohara, Akimasa Nakao |
Under the heparinized hydrophilic catheter-bypass between splenic and femoral vein, the hepatoduodenal and hepatogastric ligaments were Iigated to interrupt hepatic blood inflow in 5 dogs, and temporary interruption of hepatic blood inflow for 15, 30, 60, 90 minutes were performed in each 5 dogs.
In this experimental study, changes of systemic blood coagulation and fibrinolysis, and histological changes of the liver were investigated periodically.
Continuous interruption of hepatic blood inflow decreased blood coagulability gradually. Temporary interruption of hepatic blood inflow for more than 60 minutes caused remarkable decrease of blood coagulability after declamp, and histologically fibrin deposites were found in sinusoid and portal vein of Glisson's area, indicating that apparent DIC occurred in the liver at more than 60 minutes after clamp. One hour after declamp of 90 minutes interruption of hepatic blood inflow, most of fibrin deposites disappered but severe degeneration of endothelial cell of sinusoid and hepatocyte were observed, indicating the disturbance of hepatic microcirculation which caused acute liver failure and systemic DIC, finally death in shock.
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