J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 2636KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 86(2): 173-178, 1985

Original article

EXPERIMENTAL STUDY ON INFLUENCE OF OBSTRUCTIVE JAUNDICE AND VAGOTOMY UPON STRESS ULCER IN RATS

First Department of Surgery, Tohoku University School of Medicine, Sendai, Japan

Hidenobu Miyakawa, Jin-ichi Kameyama, Yoshio Konno, Hideo Narui

The effect of water immersing and restraint stress upon the gastric acid secretion and gastric mucosal defensive factors was investigated in rats with special reference to the influence of obstructive jaundice and vagotomy. The results obtained were as follows.
1) Water immersing and restraint stress ulcer may be caused by increased gastric acid secretion and deteriorated gastric defensive factors.
2) Enhanced ulceration in jaundiced rats may be caused by severely damaged gastric defensive factors, rather than by the increased gastric acid secretion.
3) Vagotomy itself, cannot inhibit stress ulceration completely, especially under the condition of damaged gastric defensive factors.

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