J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 5309KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 86(2): 160-172, 1985

Original article

CLINICAL STUDY ON GLUCOSE INTOLERANCE AND INSULIN RESPONSE IN OBSTRUCTIVE JAUNDICE

1) Department of Surgery, Jichi Medical School, Tochigi, Japan
2) Department of Gastroenterology, Jichi Medical School, Tochigi, Japan

Kogoro Kasahara1), Yoshikazu Yasuda1), Asao Futenma1), Yuichi Yamashita1), Sumio Tenmoku1), Akiyoshi Kashii1), Kyotaro Kanazawa1), Takeo Yamanaka2), Ken’ichi Ido2)

Insulin responses to oral glucose loads were studied in patients with obstructive jaundice and compared with those of other liver diseases (fatty liver, chronic hepatitis and liver cirrhosis), pancreatic diseases, and definite diabetes mellitus. Compared with their corresponding glucose intolerance, high insulin responses were characteristic in fatty liver, chronic hepatitis and liver cirrhosis, and insulin responses and insulinogenic index decreased in chronic hepatitis and liver cirrhosis as glucose intorelance progressed. In obstructive jaundice with the pancreatic ducts stenotic or obstructed, insulin responses were suppressed in comparison with their corresponding glucose intolerance, and also insulinogenic index were below 0.5 in most of the cases. However, in obstructive jaundice with the pancreatic ducts intact, high insulin responses were observed in almost half of the cases with insulinogenic index above 0.5, and insulin response and insulinogenic index decreased as glucose intolerance progressed.
While most cases of fatty liver, chronic hepatitis and liver cirrhosis with insulinogenic index above 0.5 were distributed in non-diabetes zone in ΣBS-ΣIRI plane (Kosaka’s), those with insulinogenic index below 0.5 were distributed in intermediate zone. Most cases with obstructive jaundice with pancreatic ducts stenotic or obstructed, had insulinogenic index below 0.5 and were distributed in diabetes zone. However, half of cases with obstructive jaundice with pancreatic ducts intact, had insulinogenic index above 0.5 and their distribution in non-diabetes zone, while the other half had insulinogenic index below 0.5 and their distribution in diabetes zone. Therefore, it may be concluded that insulin responses increase at the early stage of obstructive jaundice mainly under influence of liver dysfunction itself, but that insulin response is suppressed at later stage of obstructive jaundice as pancreatic islets are affected.

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