J.Jpn. Surg. Soc.. 85(7): 643-653, 1984
Original article
EFFECT OF TOTAL PARENTERAL NUTRITION ON THE NUTRITIONAL STATUS AND IMMUNOCOMPETENCE IN HOST AND ON THE TUMOR GROWTH
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Kobe University, School of Medicine, First Department of Surgery, Kobe, Japan Muneyoshi Nishijima, Harumasa Ohyanagi, Yoichi Saitoh |
The 4-nitro-quinoline-1-oxide induced Sato Lung Carcinoma was transplanted subcutaneously on the back of Donryu rats. Rats were controled by TPN, low calory infusion or oral feeding for one or two weeks. Each group was subdivided into chemotherapy and non chemotherapy group. Chemotherapy was performed with adriamycin or ACNU.
Tumor bulk was bigger in the well nourished TPN rats than in malnourished group,r evealing an acceralated tumor growth by TPN. Despite no significant change in polyamine level and phospholyration activity, thymidine kinase activity and mitotic index in tumor were significantly higher in TPN than in low calory infusion.
Compared to the results of low calory infusion, higher activity of IgG, IgM plaque forming cells and lymphocytic blastformation by PHA was suggested the good maintenance of both cellular and humoral immunity in well nourished rats.
There was no positive evidence to support the facilitated effect of chemotherapeutic agents in TPN. However, TPN decreased an incidence of adverse reactions of chemotherapy such as loss of weight, leukopenia. Survival rate of rats at nine weeks after treatment also showed the favorable effect of TPN on chemotherapy.
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