[
Abstract]
[
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[Members Only And Two Factor Auth.] J.Jpn. Surg. Soc.. 85(5): 409-414, 1984
Original article
HEMODYNAMIC EFFECTS OF DBcAMP IN PATIENTS WITH LOW CARDIAC OUTPUT SYNDROME FOLLOWING OPEN-HEART SURGERY
Hemodynamic effects of DBcAMP given at 0.05 to 0.3 mg/kg/min for 30 minutes to patients with low cardiac output less than 2.2l/min/m
2, to patients on IABP and on dopamine or dobutamine were investigated after open-heart surgery. Hemodynamic improvements were observed in cardiac index from 1.81±0.3 (mean±SD) to 2.56±0.40l/min/m
2 (p＜0.001), stroke index from 20.5±5.2 to 26.4±5.2ml/best/m
2 (p＜0.001). TRP decreased from 1963.8±682.8 to 1153.9±449.0 (p＜0.001). These changes were similar to those of Groups II (3.0≧Cl≧2.2l/min/m
2) and of Group III (Cl>3.0l/min/m
2). Increases were also observed in CI from 2.28±0.67 to 2.96±0.671/min/m
2(p＜0.001) and in stroke index from 24.4±7.2 to 29.5±6.4ml/best/m
2 (p＜0.001) and significant decreases were observed in TPR and PVR in patients receiving dopamine or dobutamine.
These results strongly suggest the inotropic action of DBcAMP was independent on the beta receptor activity and could be a powerful adjunct in the treatment of low cardiac output patients on whom the dopamine or dobutamine was ineffective.
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