J.Jpn. Surg. Soc.. 83(10): 1218-1227, 1982
Original article
MNNG-INDUCED REMNANT STOMACH CARCINOMA IN RATS
|
1st Department of Surgery, Tottori University School of Medicine, Yonago, Japan Hideaki Nishidoi |
One hundred and seventy eight male Wistar rats were divided into 5 groups : Group 1 received Billroth II reconstruction, group 2 short Roux-Y reconstruction, group 3 long Roux-Y reconstruction.
Group 4 received gastrotomy alone, and group 5 received no surgical procedure as the controls. Half of the rats in each group were given 120μg/ml of MNNG and 0.4% Tween 60 in the tap water ad libitum for 6 months postoperatively. The remaining half received no carcinogen treatment for histologic examination of the gastric mucosa.
Adenocarcinoma developed in the remnant stomach with the incidence of 38.9% in group 1, 25.0% in group 2 and 7.1% in group 3. All of the carcinomas were found in the anastomotic regions. In contrast, gastric carcinomas developed in 15.0% (group 4) and 9.5% (group 5) of the controls. The incidence of carcinoma in group 1 was significantly high (p＜0.05) as compared to those in group 3 or group 5.
Histological examination revealed that the evidences of erosive gastritis and atrophic gastritis were frequently recognized in the gastric mucosa of the anastomotic regions in group 1. Acidity in the remnant stomach was lower in group 1 than in group 2 and 3.
On the basis of the above, it is reasonable to assume that the reflux of the duodenal juice (including bile) is substantially related to the development of the carcinoma of the remnant stomach.
To read the PDF file you will need Adobe Reader installed on your computer.