J.Jpn. Surg. Soc.. 83(4): 345-351, 1982
Original article
MYOCARDIAL TEMPERATURE GRADIENTS DURING AORTIC CROSS CLAMP IN COLD CHEMICAL CARDIOPLEGIA
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Thoracic and Cardiovascular Surgery, Nippon Medical School Junichi Ninomiya, M.D., David C. Mac Gregor, M.D.*), Frederick W. Heineman, M.D.*) |
In 11 dogs after the cardiopulmonary bypass at 28℃, stenosis or occlusion of left cicurmflex branch of coronary artery was made with adenosine, and perfusion with cold (4℃) cardioplegic solutions through aortic root was performed. Temperatures were measured from the subepicardium, mid-wall and subendocardium of the left ventricle in the CCA and LAD distributions and other 6 points.
Infusion flow distribution of perfusate was measured simultaneously by administration of 3 types of radioactive microsphere into the perfusate.
Myocardial cooling with cardioplegic solution was transmurally uniform under any condition of coronary artery, but was significantly impaired (p＜0.01) in the CCA region by both critical stenosis (17.4±1.2℃) and occlusion (23.6±0.4℃) compared to control (8.3±0.5℃) due to reduced regional tissue perfusion flow (r=0.62, p＜0.001).
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