J.Jpn. Surg. Soc.. 83(2): 220-230, 1982

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Original article

EXPERIMENTAL STUDIES ON THE PORTAL HYPERTENSIVE DOGS PRODUCED BY THE WHOLE LIVER COMPRESSION

We had developed a new method of the whole liver compression to produce evperimental portal hypertensive models. This time we studied the liver pathology following the compression and the longlasting effect of this method to make clear the pathogenesis of these models. Fifteen dogs were divided into three groups. Group I had moderate increase in portal pressure with an average of 283 mmH₂O Group II had a marked increase in that with an average of 356 mmH₂O. Group III served as the control. The following results were obtained :
In group I, the most part of liver escaped from the compressing material had a marked enlargement and portal pressure dropped to the previous level on 6 months after the surgery. In group II, the liver was compressed well and the portal pressure remained high level with an average of 304 mmH₂O on 6 months after the surgery. And in the microscopic studies in group II, the liver specimens showd a slight increase in fibrous connective tissue with thin septum formation and the esophageal specimens showed slight to moderate dilatations of the submucosal veins by 6 months after the compression.

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