J.Jpn. Surg. Soc.. 83(1): 27-37, 1982

---

Original article

STUDY ON THE IMMUNOLOGICAL REACTIVITY OF CANCER PATIENTS
I. CYTOSTATIC ACTIVITY OF PERIPHERAL BLOOD MONOCYTES AGAINST ALLOGENEIC CULTURED TUMOR CELLS IN CANCER PATIENTS

To evaluate the host immune response toward the tumor, cytostatic activity of peripheral blood monocytes against allogeneic cultured tumor cells derived from the same organs as that of the patients with lung cancer, gastric cancer, and breast cancer was examined. Cytostatic activities of these patients were neither augmented nor suppressed significantly as compared with those of controls such as normal healthy persons, patients with benign diseases and patients with malignancies other than respective cancer, however, the degree of peripheral blood monocyte-mediated cytostasis differed from one cell line to others. There was no correlation between the cytostatic activity of peripheral blood monocytes and the stages of cancer. Moreover, cytostatic activity of peripheral blood monocytes was less sensitive to the tumor burden in patients. Similarly, the activity of monocytes in lung cancer patients was not sensitive to conventional modalities of anticancer treatments such as surgery, radiotherapy, chemotherapy and their combination. However, adequate nonspecific immunotherapy with Nocardia rubra cell-wall skeleton augmented the cytostatic activity of peripheral blood monocytes, although adequate nonspecific immunotherapy with Mycobacterium bovis BCG cell-wall skeleton did not.

---

---

To read the PDF file you will need Adobe Reader installed on your computer.