J.Jpn. Surg. Soc.. 82(12): 1430-1441, 1981

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Original article

EXPERIMENTAL STUDIES ON STRESS ULCER PATHOGENETICALLY RELATED TO SUBARACHNOID HEMORRHAGE.
DJVICE OF A STRESS ULCER RAT MODEL PRODUCED BY COMBINATION OF SUBARACHNOID HEMORRHAGE AND MILD RESTRAINT PLUS WATER-IMMERSION

Experimental subarachnoid hemorrhage (SAH) was produced by instilling homologous arterial blood into the cisterna magna of rats. SAH alone could not produce ulcers in the gastric glandular portion, even in combination with fasting. High relative ulcer length (RUL) values were successfully produced by instillation of 0.2ml of a litter-mate's arterial blood into the cisterna magna, followed 4 days later by restraint plus water immersion for 3 hours. This model was named as the SAH-stress model.
Using this model, experimental investigation was performed on effects of various ulcer-preventing measures. Their effects on blood distribution in the gastic mucosa and acidity of gastric juice were also investigated. From these results, it was considered that, in the SAH-stress model of the present investigation, SAH-induced hypersensitivity or abnormal excitability of the autonomic nervous center had pre-existed, and, on this basis, a relatively mild stress had weakened the gastric defensive factor and strengthened the gastric aggressive factor via the sympathetic and the parasympathetic nervous systems, thus resulting in ulcer formation.
In some clinical cases of SAH, postoperative stress ulcer may be induced by the mechanism similar to the present model, and it is supposed that some of the ulcer-preventing measures in the present study may be applied clinically.

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