J.Jpn. Surg. Soc.. 82(10): 1212-1223, 1981

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Original article

EXPERIMENTAL STUDIES ON THE ROLE OF THE AUTONOMIC NERVEOUS SYSTEM IN STRESS ULCER-MAINLY ON THE MEASUREMENT OF GASTRIC BLOOD FLOW AND GASTRIC MOTILITY

For the purpose of exploring the pathogenesis of stress ulcer and the mechanism by which stress affects it, the correlation between stress ulcer formation and changes of gastric blood flow, gastric motility and gastric acidity were examined under the condition of restraint and water immersion stress in both intact and vagotomized rats.
In the intact rats, the gastric motility was increased and reached the climax in five hours after the stress, when the blood flow of gastric wall was significantly down to about 35% of the pre-stress blood flow. The blood flow thereafter remained unchanged, and hyperacidity and gastric ulcer were observed in all rats. On the other hand, in the vagotomized rats, the acceleration of gastric motility was rarely observed. The gastric blood flow was decreased to 55% of the pre-stress blood flow at 8 hrs after the stress. But the hyperacidity was not observed, and stress ulceration was significantly restrained. Furthermore, the decrease of blood flow in the gastric wall and stress ulceration were prevented not only by atropine, but also by α- or β-adrenoreceptor blocking agents.
The results suggest that the stress ulcer should be produced by the sympathetic as well as parasympathetic nervous activities responsible for the disturbance of gastric mucosal microcirculation, in addition to the acceleration of gastric motility and acidity.

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