J.Jpn. Surg. Soc.. 82(5): 435-440, 1981
Original article
THE SIGNIFICANCE OF SURGICAL TREATMENT FROM THE VIEWPOINT OF PATHOGENESIS OF GRAVES' DISEASE
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The Second Department of Surgery, Shinshu University School of Medicine Akira Sugenoya, Masao Makiuchi, Makoto Miyakawa, Masaru Kobayashi, Gengo Kaneko |
The results were as follows:
1) In the 12 postoperative patients dividing into two groups, i.e. 3 euthyroid and 9 hyperthyroid (recurrent) patients, there existed significant differences (p＜0.005, respectively) in the macrophage migration inhibition factor test compared with healthy controls as well as the untreated group did.
2) Those patients who showed either negative in both autoantibodies to thyroglobulin and thyroid microsomal antigen or low titers of only microsomal antibody with negative test for thyroglobulin prior to surgery, have had satisfactory results after subtotal thyroidectomy.
3) The patients with both positive antibodies or high titers of microsomal antibody appear to have a tendency resulting in postoperative recurrence or hypothyroidism.
4) In the most patients with eumetabolic state after surgery, there seems to be a fall in the microsomal antibody level passing more than two years postoperatively.
These results suggest that 1) surgery would partly influence on the immunological condition, especially on the humoral immunity; and 2) the classical autoantibodies can be indirect indices representing existences of thyroid-stimulating antibody or other pathological immune phenomena.
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