J.Jpn. Surg. Soc.. 82(3): 237-251, 1981
Original article
THE EFFECT OF VAGOTOMY ON THE INTRAMURAL NERVE ELEMENTS OF THE RAT STOMACH
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Department of Gastroenterological Surgery, Wakayama Medical College (Director: Prof Masaharu Katsumi) Hideo Mishima |
No histological change in the intramural nerve cells and nerve fibers was observed. Histochemical observations of the vagal nerve after vagotomy showed a decrease in acetylcholinesterase activity at the distal part. No histochemical alteration of acetylcholinesterase activity was demonstrated in the central part of extramural vagal nerve, intramural nerve fibers or intramural plexus. Moreover, no fluorescent histochemical change was demonstrated in the aminergic fibers.
The electron microscopic findings of the synaptic structure in the myenteric plexus after vagotomy revealed presynaptic terminal degenerations. Such degenerations after vagotomy were observed mainly in the boutons containing many small clear vesicles, probably cholinergic terminals, but rarely observed in the boutons with many large dense-cored vesicles, probably P-type terminals. No degeneration was observed in the boutons having many small dense-cored vesicles, probably aminergic terminals.
The only effect of vagotomy on the neuron was dispersion of granulated endoplasmic reticulum, indicating transneuronal degeneration. Degeneration was found in some nerve endings within the muscle layer of the stomach also. Therefore, it appears that some nerve fibers of the vagus are directly distributed to the muscle cell without passing through the intramural plexus.
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