J.Jpn. Surg. Soc.. 82(1): 86-95, 1981

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Original article

STUDIES OF FAT METABOLISM AFTER MAJOR RESECTION OF THE PANCREAS

The purpose of this study was to evaluate changes of fat metabolism, including serum lipids, postheparin lipolytic activity (PHLA) and fat deposition in the liver, in relation to the changes of glucose tolerance after major resection of the pancreas in dogs.
1) Immediately after resection of 90% or more of the entire pancreas, diabetes occured and serum lipids increased with a corresponding decrease in PHLA. A large amount of fat deposition was observed in the liver.
2) During the early period after resection of 70 to 90% of the entire pancreas, fat metabolism and glucose tolerance was maintained in the normal range. After that, glucose tolerance gradualy decreased and so-called Sandmeyer’s diabetes developed. When diabetes developed, the serum lipids increased with a decrease in PHLA and fat deposition was observed in the liver.
3) After resection of less than 70% of the entire pancreas, glucose tolerance was maintained well and hyperlipemia or intrahepatic fat deposition did not develop. However, slight a change in PHLA was observed during 26-week postoperative observation.

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