J.Jpn. Surg. Soc.. 82(1): 42-50, 1981

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Original article

A STUDY ON RELATIONSHIP BETWEEN MITOTIC ACTIVITY OF CANCER CELLS AND VARIOUS FACTORS OF GASTRIC CANCER PATIENTS

An in vivo stathmokinetic method was used to analyze the mitotic activity of cancer cells from 47 gastric cancer patients. The effect of cellular reaction in cancer tissues on the mitotic activity of cancer cells was examined. The relationship between general factors of the patients such as immunologic activity, changes of protein metabolism and the mitotic activity of cancer cells was also examined.
Following results were obtained. (1) An inverse correlation was found between the mitotic activity of cancer cells and the degree of lymphoid cell infiltration in cancer tissues. (2) There was a tendency to decrease in the mitotic activity of cancer cells paralleling with the increase in degree of delayed skin hypersensitivity to PPD and PHA and in number of lymphocytes in peripheral blood. (3) Inverse correlations between the mitotic activity of cancer cells and the values of hemoglobin, hematocrit, albumin and ratio of albumin/globulin were found. Cancer cells showed a tendency to increase in the mitotic activity paralleling with the increase in α₁ and α₂ globulin of peripheral blood. (4) Highly significant correlations between the mitotic activity of cancer cells and the activity of lactec dehydrogenase (LDH) and its isoenzymes (LDH_3-5) in peripheral blood were observed.
These results suggest a posibility that the mitotic activity of cancer cells is regulated by the infiltrating lymphoid cells in cancer tissue and promoted by impairment of cellular immunity. Moreover, it may be estimated that protein metabolism and the function of erythrocyte formation are impaired and that the activity of LDH derived from cancer cells increases in peripheral blood, paralleling with the increase in the mitotic activity of cancer cells.

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