J.Jpn. Surg. Soc.. 81(12): 1559-1569, 1980

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Original article

EXPERIMENTAL STUDIES ON THE SELECTIVE PROFOUND HYPOTHERMIA OF THE ABDOMINAL VISCERAS

In the present study, an effort was made to establish the procedure for selective profound hypothermia of the abdominal visceras. The procedure may enable the surgeon to perform otherwise difficult or impossible resections of the liver and pancreas.
In 6 mongrel dogs, hemodynamic alterations were investigated during 60 minutes normothermic vascular exclusion of the abdominal visceras by occluding the aorta and inferior caval vein just above the diaphragma. The 60 minutes occlusion was followed by a hypoperfusion condition and a severe acidosis in the cranial half of the body.
In 8 mongrel dogs, the 60 minutes selective profound hypothermia below 20°C of the abdominal visceras was performed after occluding the aorta and inferior caval vein, with an aid of extracorporeal circuit. Pooled blood in the splanchnic region during hypothermic isolation was warmed and introduced to jugular vein by extracorporeal circuit to maintain the hemodynamic state in the cranial half of the body. 5 of 8 dogs survived 2 weeks after the procedure with minimal hepatic damage.
These results are encouraging to warrant a clinical application of the procedure in patients undergoing hepatectomy and regional pancreatectomy.

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