J.Jpn. Surg. Soc.. 81(8): 746-755, 1980
Original article
HEPATIC REGENERATION AND MITOCHONDRIAL FUNCTIONS AFTER PARTIAL HEPATECTOMY IN YOUNG AND ADULT RATS
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First Department of Surgery, Hokkaido University School of Medicine (Director: Prof. Yoichi Kasai) Yoshihide Shinada |
1) Respiratory control ratio and ADP/O ratio increased 24 hours after hepatectomy and then decreased below normal level. These ratios increased again 3 and 4 days in young and adult rats, respectively and returned to normal levels after 2 weeks.
2) The amount of cytochromes in liver mitochondria rapidly decreased after hepatectomy in both groups. However, it increased earlier in young rats.
3) ATP synthesis in liver mitochondria was greater in young rats than in adult rats before and after hepatectomy.
4) Liver weight gain was greater in young rats than in adult rats after hepatectomy.
5) The body weight of growing young rats returned to the level of control group 2 weeks after hepatectomy.
Young rats have greater energy producing abilities and showed rapid liver regeneration without growth retardation compared to adult rats.
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