J.Jpn. Surg. Soc.. 81(7): 640-653, 1980

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Original article

AN EXPERIMENTAL STUDY ON PORTAL BLOOD FACTORS INFLUENCING FUNCTION OF REGENERATING LIVER AFTER PARTIAL HEPATECTOMY

Liver regeneration in response to partial hepatectomy is altered significantly by both quantitative and qualitative factors in the portal venous blood. This study aimed to evaluate the function of canine regenerating liver after 40% hepatectomy with circulatory change or evisceration by means of indocyanine green Rmax.
Portacaval shunt with or withoyt infusion of glucose, or amino acids, or insulin and glucagon into the liver via proximal portal vein stump revealed poor ICG Rmax during a 6 week period of follow up. Portacaval transposition showed good regeneration accompanying with marked recovery of ICG Rmax, but when the procedure was added an arterio-venous fistula at the femoral region, the ICG Rmax decreased remarkably. These results suggested an appropriate volume of the portal blood flow is necessary for influencing the regeneration of the liver.
The recovery of ICG Rmax after both duodenectomy and pancreaticoduodenectomy was poor, but the recovery was fairly good after pancreatectomy only. There was significant discrepancy between morphological change and functional recovery in the regenerating liver after 40% hepatectomy, but it was suggested that an humoral factor originated from the duodenum may play an important role in the influence of hepatic regeneration.

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