[
Abstract]
[
Full Text PDF] （in Japanese / 8263KB）
[Members Only And Two Factor Auth.] J.Jpn. Surg. Soc.. 81(7): 594-607, 1980
Original article
EXPERIMENTAL AND CLINICAL STUDIES ON SENSITIVITY TESTS OF HUMAN TUMOR CELL TO ANTICANCER AGENTS USING NUDE MICE AND SUCCINIC DEHYDROGENASE INHIBITION (SDI) TEST
In cancer chemotherapy, the most sensitive agent against individual tumors should be preferably used. For this purpose, the sensitivity tests using nude mouse as an
in vivo model and
in vitro SDI test have been investigated. Cancer cells from 95 cases were transplanted into the nude mice and treated with intraperitoneal administration of Mitomycin C (3 mg/kg), 5-Fluorouracil (25 mg/kgx3) or Cyclophosphamide (200 mg/kg), of which 70 were evaluated by microscopic changes appeared on the specimens. The rate of positive sensitivity against tumors was 37.1 % in Mitomycin C, 28.6% in 5-Fluorouracil and 21.4% in Cyclophosphamide respectively. The sensitivity of each agent by “nude mouse” method indicated a good correlation with clinical therapeutic effects. In the same cases: the sensitivity of individual tumors ware tested by
in vitro SDI method. These results by
in vivo and
in vitro tests showed fairly good agreement. From these results, it seems to be very usefull to evaluate the sensitivity of various anticancer agents by the microscopic changes of human tumor cells transplanted into nude mice after
in vivo administration of them.
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