J.Jpn. Surg. Soc.. 81(5): 416-426, 1980

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Original article

EXPERIMENTAL STUDIES ON THE INFLUENCE OF JAUNDICE ON GASTRIC MUCOSAL BARRIER

The influences of jaundice on gastric mucosal barrier were studied in view of gastric mucosal permeability and transmucosal electrical potential difference in 21 dogs with Heidenhain pouches. Heidenhain pouches were irrigated with various test solutions, and net fluxes of H⁺ (⊿H⁺) and Na⁺ (⊿Na⁺) as well as transmucosal electrical potential difference (PD) were measured before and after obstructive jaundice by the ligation of the common bile duct.
The results obtained are as follows:⊿H⁺, ⊿Na⁺ and PD were measured in 15 dogs using the test solutions of 100 mN HCI, 150 mN HCI and 20 mM taurocholic acid in addition to 100 mN HCI (20 mM TCh). The increases in net fluxes of H⁺ and Na⁺ and the decrease in PD were observed, when the test solution of 20 mM TCh was used. However, there was no difference in the changes of ⊿H⁺, ⊿Na⁺ and PD between before and after jaundice. Also, ⊿H⁺, ⊿Na⁺ and PD were measured in six dogs using the test solutions of 100 mN HCl and concentrations of 1 to 35 mM TCh in addition to 100 mN HCl.PD values determined every 3 minutes were summed up, and this was designated as ΣPD. There was dose-response relationship between the concentration of TCh and the values of ⊿H⁺, ⊿Na⁺ and ΣPD. This relationship was observed in both normal and icteric dogs. The maximum values of ΣPD, ⊿H⁺, ⊿Na⁺ were obtained at TCh concentration of 20 mM. Further, the concentrations of TCh to attain 50% values of ⊿H⁺, ⊿Na⁺ and ΣPD of the maximum value were calculated from the doseresponse curve, and this was designated as ED₅₀. There was no difference in the ED₅₀ for ⊿H⁺, ⊿Na⁺ and ΣPD between before and after jaundice.
These results suggest that jaundice itself exerts no influence on gastric mucosa! barrier, viewed from gastric mucosal permeability and transmucosal electrical potential difference.

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