J.Jpn. Surg. Soc.. 81(4): 317-329, 1980
Original article
HISTOPATHOLOGICAL STUDIES OF EXPERIMENTAL PANCREATIC CANCER PRODUCED BY 7 • 12-DIMETHYLBENZANTHRACENE (DMBA) IN RATS
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First Department of Surgery, Osaka City University Medical School, Osaka, Japan Kento Yamashita |
Following results:
1) Incidence of the pancreatic carcinoma was 68.4%.
2) Histological patterns of pancreatic cancer were tubular adenocarcinoma in 15 (14.2%) out of 106 rats, poorly differentiated adenocarcinoma in 61 (58.1 %), adenosquamous carcinoma in 4 (3.9%),acinar cell carcinoma in 9 (8.5%), undifferentiated carcinoma in 13 (12.4%) and pseudosarcoma in 4 (3.9%). Most of cancers originated from ductal components.
3) These tumors had direct invasion to the neighboring organs in 35 (33.0%), cancer cell emboli in the lymphatic vessels in 23 (21.7%), venous infiltration in 17 (16.0%), metastasis to the lymph nodes in 18 (17.0%), lung metastasis in 2 (1.9%), intraabdominal dissemination in 48 (45.3%). Typical carcinomatous peritonitis with haemorrhagic ascites was also observed in 35 (33.0%).
4) Non-cancerous tumors showed various kinds of proliferation and atypism of ductal epitheliums associated with cellular and structural atypism. These tumors could not distinguished from genuine cancer.
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