J.Jpn. Surg. Soc.. 81(4): 306-316, 1980
Original article
A STUDY ON MITOTIC ACTIVITY OF HUMAN GASTRIC CANCER TREATED WITH VINCRISTINE SULFATE
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*) First Department of Surgery, Kobe University School of Medicine Yoshiki Tabuchi*), Kazunori Inoue*), Masaki Minami*), Saishun Boku*), Michio Kato*), Yasuhiko Takiguchi*), Yoshio Murayama*), Katsunori Kawaguchi*), Takao Mitsuno**) |
In metaplastic mucosa, almost all mitotic cells (96.4%) were found in the lower half segment of the mucosa. Therefore, the segment of the mucosa was thought to be the growth area, and mitotic index (MI) was calculated in the area. In cancer tissue as well as metaplastic mucosa around the cancer lesion,VCR produced the increase in MI due to the increase in metaphase. Following a single dose (0.02 mg/kg) of VCR, a rapid and linear increase in MI was found in the metaplastic mucosa during 16 hours. The average value of MI analyzed at 16 hours after VCR-administration was 97.3 in the metaplastic mucosa and 84.1 in the cancer tissue. Average cell production rate was estimated 4.6 cells/1,000 cells/hr in the metaplastic mucosa and 3.9 cells/1,000 cancer cells/hr in the cancer tissue. Ttherefore, the mitotic activity of the former was thought to be higher than the latter.
Cancer tissue showed the changes of MI in the various states; the increase in MI was paralleled with the increase in the size, the degree of stage and in the invasive layers of the gastric wall. Average MI of early cancer was 60.2 and that of advanced cancer was 95.6. Poorly differentiated adenocarcinoma showed a higher value (average, 91.0) of MI than that (average, 78.1) of differentiated adenocarcinoma. MI of the metastatic lesion showed also a higher value (average, 120.7) than that of the primary lesion (average, 95.0). However, the correlation between average MI and the location, degree of fibrous reaction and type of infiltrative growth in the cancer tissue was not found.
The results were discussed in comparison with the results obtained by other investigators using stathmokinetic and autoradiographic techniques.
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