J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text HTML] [Full Text PDF] （in Japanese / 1260KB） [Members Only]

J.Jpn. Surg. Soc.. 120(1): 24-29, 2019

Feature topic

CURRENT CLINICAL PRACTICES FOR TREATING PERIOPERATIVE ANTIBIOTIC-ASSOCIATED DIARRHEA

1) Department of Infectious Diseases, Hiroshima University Hospital, Hiroshima, Japan
2) Department of Surgery, Hiroshima University Graduate School of Medicine,, Hiroshima, Japan

Hiroki Ohge1), Yusuke Watadani2), Shinnosuke Uegami2), Norimitsu Shimada2), Raita Yano2), Atsushi Mukoda2), Kenichiro Uemura2), Yoshiaki Murakami2), Taijiro Sueda2)

Clostridioides (Clostridium) difficile infection is one form of perioperative antibiotic-associated enteritis. While the incidence was reported to be 0.28% after gastrointestinal surgery, C. difficile infection has been a focus due to a higher mortality rate, longer hospital stays, and higher medical cost. Moreover, the commonly used rapid test for the diagnosis of this infection has a problem of low sensitivity. The recent PCR method may resolve this problem, although it involves a higher cost. Another issue of C. difficile infection is recurrence. Fidaxomicin or bezlotoxumab are novel drugs to prevent recurrence. Further investigations are needed to determine the appropriate usage of these medications from the viewpoint of cost-effectiveness.

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