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J.Jpn. Surg. Soc.. 119(3): 293-298, 2018
SERUM BIOMARKER TREFOIL FACTOR FAMILY PEPTIDES COULD PROMOTE PARTICIPATION IN BLOOD TEST-BASED BREAST CANCER SCREENING
Breast cancer remains a common malignancy in women, but the participation rate in breast cancer screening programs in Japan is still low, possibly due to their perceived inconvenience. Breast cancer screening with mammography or ultrasound is provided for women beginning at 40 years of age by local governments in Japan. If breast cancer could be screened through a blood test instead of mammography or ultrasound, the participation rate in screening examinations would likely increase. Trefoil factors (TFFs) are small, stable peptides secreted by the mammalian epithelial mucous-secreting cells in the gastrointestinal tract. TFFs constitute a family of three peptides (TFF1, TFF2, and TFF3) that are widely expressed in a tissue-specific manner in the body. Serum TFF1 and TFF3 levels were found to be significantly higher and serum TFF2 levels significantly lower in breast cancer patients. The area under the curve (AUC) of receiver operating characteristics of TFF1, TFF2, and TFF3 was 0.69, 0.83, and 0.72, respectively. The AUC of the combination of TFF1, TFF2, and TFF3 was 0.96. Serum TFFs are therefore significant biomarkers for breast cancer screening.
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