J.Jpn. Surg. Soc.. 125(5): 415-422, 2024

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Feature topic

CAN RADIOTHERAPY FOR BREAST CANCER REPLACE SURGICAL RESECTION?

Historical experience with radiotherapy and several clinical trials have shown that the tumor control rate of conventionally fractionated radiotherapy using X-rays is considerably inferior to that of surgery. However, with recent advances in radiotherapy technology and the use of particle therapies, the possibility of controlling breast cancer with radiotherapy is increasing. Partial breast irradiation using stereotactic body radiotherapy or intensity-modulated radiotherapy was performed as preoperative treatment for partial mastectomy, for patients who did not wish to undergo resection, or for primary breast cancer with distant metastases, and the treatment results were evaluated. Particle therapy, especially heavy-ion radiotherapy using carbon ion, has a biological effect ratio three times that of X-rays, and a clinical trial conducted at QST Hospital, National Institute for Quantum and Science and Technology, has shown a high local control rate.

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