J.Jpn. Surg. Soc.. 119(4): 366-372, 2018

---

Feature topic

3D ORGAN CONSTRUCTION OF THE HEART AND ITS APPLICATION TO THE SURGICAL FIELD

To achieve 3D organ construction of the heart, various elemental technologies have been developed, with tissues such as the myocardium and heart valves constituting the heart being embodied. As an example, this article introduces mechanical engineering efforts such as 3D printer technology, which can precisely reproduce morphology with artificial material up to the internal structure of the heart, and bioprinter technology, which can stack cells instead of ink. In addition, biochemical approaches, such as decellularization technology to replace not only the cells of heart valves but also the entire heart, are described. In vivo tissue engineering efforts can construct 3D tissues in vivo after transplantation of a collagen scaffold produced in vivo or in vitro. The current status of 3D organ construction of the heart is presented, and the feasibility of clinical applications in the future is discussed.

---

---

To read the PDF file you will need Adobe Reader installed on your computer.