J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text HTML] [Full Text PDF] （in Japanese / 1334KB） [Members Only]

J.Jpn. Surg. Soc.. 113(5): 435-440, 2012

Feature topic

REGENERATIVE MEDICINE USING CELL-SHEET ENGINEERING

1) Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University (TWIns), Tokyo, Japan
2) Department of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University, Tokyo, Japan

Nobuo Kanai1)2), Masayuki Yamato1), Takeshi Ohki1)2), Masakazu Yamamoto1), Teruo Okano1)

We have developed a novel strategy for regenerative medicine to recover tissue functions using temperature-responsive cell culture surfaces. To overcome the disadvantages of conventional methods such as the usage of single-cell suspension injections and biodegradable polymer scaffolds, we use transplantable cell sheets fabricated with temperature-responsive culture surfaces for cell delivery. Here, we summarize our progress in promoting regenerative medicine using cell-sheet engineering with respect to research and regulatory systems and describe recent challenges in the standardization of cell-sheet engineering.

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