J.Jpn. Surg. Soc.. 111(6): 368-372, 2010

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Feature topic

PERIOPERATIVE NUTRITIONAL MANAGEMENT IN VARIOUS CLINICAL CONDITION: DISEASES OF LOWER DIGESHIVE SYSTEM

The systemic inflammation-related nutritional nutritional index based on circulating levels of C-reative protein and albumin can determine which colorectal cancer patients are vulnerable not only to tumors in which uncontrolled upregulation of the local interleukin (IL)-1-IL-6 network occurs but also to a specific tumor-acquired deleterious response that has developed or is developing in the host. These patients may first require a therapeutic strategy to control the IL-1-IL-6 network system in the tumor, both to reverse IL-6-induced metabolic alterations to regain body mass during nutritional support and to benefit from adjuvant anticancer therapy by increasing the tumor response to treatment and reducing treatment-related adverse reactions. The early detection of this critical manifestation allowing for early intervention is important. Although further prospective studies are required to confirm our results, the findings reported here suggest that specific targeting of the IL-1-IL-6 pathway may be a promising new approach for the treatment of cancer-related cachexia.

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