J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 1782KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 99(7): 419-424, 1998

Feature topic

CARBOHYDRATE CHAINS AND HEMATOGENOUS METASTASIS：A REVIEW

Institutions：Department of Surgical Oncology, The University of Tokyo, School of Medicine, Tokyo, Japan

Yutaka J.Kawamura, Tetsuichro Muto

It is well known that the expression of carbodydrate chains on cell changes during the development and progression of carcinoma. Some carbohydrate chains have been used in clinical practice as tumor markers. Some, such as sialyl Lewis a (CA19-9), sialyl Lewis X, and Tn, are known to function as adhesion molecules. However, their role in the development of hematogenous metastasis is still controversial. In this paper, many investigations concerning this issue are reviewed. Clinical trials for treatment of patients with advanced cancer using carbodydrate chains are also mentioned.

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