J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 926KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 99(4): 256-263, 1998

Editorial

N-3 POLYUNSATURATED FATTY ACIDS IN SURGICAL NUTRITION

1) First Department of Surgery, Chiba University School of Medicine, Chiba, Japan
2) Laboratory Animal Center, School of Medicine, Chiba University, Chiba, Japan

Tsuguhiko Tashiro1), Hideo Yamamori1), Yuuichi Morishima1), Toshiyuki Sugiura, Naganori Hayashi, Katsunori Furukawa, Nobuyuki Nakajima1), Isao Itoh2)

Recent surgical nutrition includes the management of mediator to induce the stress response and immune function. N-3 polyunsaturated fatty acid (n-3 PUFA) were reported to increase the survival rate, and to improve the nutritional and immune status of septic or burned animals. N-3 PUFA also inhibited the proliferation and metastasis of cancer, and improved the cancer cachexia. N-3 PUFA decreased the production of cytokine and eicosanoid originated from n-6 PUFA, and reduced the inflammatory and stress response. Cell-mediated immunity was supressed with the reduction of cytokine. But in the stressed state, N-3 PUFA ameliorated the stress induced immunosuppression. Alteration of transcription of cytokine mRNA, changes of membrane fluidity, and reduced expression of adhesion molecule were proposed to interpret these effects.
In conclusion, n-3 PUFA can be applied for the surgical patients, especially for the critically ill patients.

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