J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 912KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 99(3): 197-200, 1998

Case report

NECROSIS OF THE HEPATOCELLULAR CARCINOMA NODULE CAN AGGRAVATE METASTASIS

1) Department of Surgery, Saiseikai Yahata General Hospital, Kitakyushu, Japan
2) Department of Surgery, Fukuoka City Hospital, Fukuoka, Japan

Takashi Matsumata1), Masahiro Okamoto1), Hiroto Ishikawa1), Tadahiro Nozoe1), Taketoshi Suehiro1), Satoru Funahashi1), Masayuki Kitamura1), Rinken Yo1), Yasunori Iso1), Takashi Maeda2)

Since the stroma of hepatocellular carcinoma is composed of sinusoid-like structures, cancer cells are readily released from the primary tumor with possible injurious consequences. A 63-year old woman with hepatocellular carcinoma underwent percutaneous ethanol injection therapy. During this treatment, tumor thrombus developed in the right hepatic vein. Partial hepatic resection was performed. Six months later, multiple nodules appeared in the lung fields. Partial necrosis may have allowed the release of cancer cells from the primary tumor. Perioperative therapy should have an effect on intrahepatic micrometastases, because removal of the main tumor can be done surgically.

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