J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 1818KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 99(2): 118-123, 1998

Editorial

GRAFT-VERSUS-HOST DISEASE AFTER ORGAN TRANSPLANTATION：DONOR AND HOST FACTORS

Department of Clinical Pharmacology, Jichi Medical School, Tochigi, Japan
Department of Surgery, Omiya Medical Center Jichi Medical school, Omiya, Japan

Eiji Kobayashi

Graft-versus-host disease (GVHD) induced by organ transplantation is dependent on both the quality and quantity of lymphocytes included in the graft. Changes in the host immune function after surgery are also important factors in the development of this disease. Based on our experimental data, GVHD after organ transplantation is reviewed
To test the reactivity of graft lymphocytes in in vivo, small bowel, liver pancreas/spleen, and heart/lung transplantations were performed using a rat in parent-to-F1 hybrid combination. All of the lymphoid organ transplants induced lethal GVHD, while liver graft did not accerated the disease after the transplantation procedure. Lymphocytes in liver grafts had a unique population and showed a low response against alloantigens in vivo. Surgical treatments also increased the susceptibility to GVHD, especially the ischemic-reperfusion procedure ; Endogenous endotoxemia triggered by reperfusion promoted the development of lethal GVHD.

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