J.Jpn. Surg. Soc.. 98(7): 639-645, 1997

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Feature topic

NEWLY-DEVELOPING THERAPIES OF PANCREATIC CANCER -IMMUNOTHERAPY, GENE THERAPY, DIFFERENTIATION THERAPY, ENDOCRINE THERAPY AND OTHERS-

Pancreatic cancer is extremely resistant to various cancer therapies, however, a variety of new therapies for pancreatic cancer have been investigated : (1) immunotherapy including cytokines like TNF, adoptive immunotherapy with lymphokine-activated killer cells or cytotoxic T-lymphocytes, and tumor vaccines using mutated Ki-ras oncoprotein or irradiated tumor cells which were transfected by cytokine genes ; (2) gene therapy including transfer of cytokine genes or antisense Ki-ras oncogene, and a combination of gene transfer of herpes simplex virus thymidine kinase and subsequent administration of ganciclovir ; (3) differentiation therapy including a quinolinone derivative, vesnarinone ; (4) endocrine therapy including cholecystokinin-receptor antagonists, CR1505 or L364,718 ; (5) heavy water, and etc. All of these therapies will be applied for the treatment of pancreatic cancer in the near future.

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