J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 3045KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 97(8): 693-697, 1996

Editorial

PATHOGENESIS OF CHRONIC ALCOHOLIC PANCREATITIS

Second Department of Surgery, Hiroshima University School of Medicine, Hiroshima, Japan

Tsuneo Tanaka, Yoshio Miura, Yasuhiro Matsugu, Kei Koide, Yasuyuki Ichiba, Kiyohiko Dohi

A useful model of chronic alcoholic pancreatitis (CAP) is not available at present. We succeeded to produce a new canine model by the combination of alcohol administration and incomplete pancreatic duct obstruction. Histopathologically, the pancreas showed fibrosis with inflammatory cell infiltration, which is similar to that of human CAP. Thereforc, we propose a following new hypothesis. If the main pancreatic duct is obstructed and pancreas juice containing alcohol stagnates for a prolonged tirne, pancreatic parenchymal cell damage by alcohol may be markedly increased, which may result in the early formation of CAP (new big duct theory). We are able to explain why CAP occurs in only a limited nurber of heavy drinkers, and why CAP occurs infrequently with liver cirrhosis.

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