J.Jpn. Surg. Soc.. 97(7): 540-544, 1996

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Feature topic

ATHEROSCLEROSIS OBLITERANCE; THROMBOLYTIC THERAPY

Thrombolytic therapy used to be considered ineffective for chronic arteriosclerotic obiterance. However, direct infusion of a thrombotic agent into the thrombus through a vascular catheter was shown to be more effective than expected.
We have performed high-dose intra-thrombic urokinase injection for arteriosclerotic obiterance of iliac and femoropopliteal arterial region since 1985. In this procedure, urokinase is infused at 10,000 unit/minute through a catheter inserted into the thrombus. In the 65 lesions treated by this metjhod, the initial success rate was 85％, and the cumulative 1-year patency rate was 72％. The mean total dose of urokinase was 620,000 units.
Here we discussed thrombolytic therapy for chronic arteriosclerosis obliterance based on our experience.

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