[
Abstract]
[
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J.Jpn. Surg. Soc.. 97(4): 312-316, 1996
Feature topic
ADJUVANT CHEMOTHERAPY FOR ADVANCED GASTRIC CANCER
For recent 40 years, many authors reported the results of adjuvant chemotherapy for advanced gastric cancer including sfluorouracil, uracil and tegafur, mitomycin C, cytosine arabinoside, OK-432, adriamycin, methotrexate, and cis-pltatin in solitary use of combinations. It is difficult to find a standard effective adjuvant chemotherapy for advanced gastric cancer in these reports. The resasons of this unclearness were as follows ; (1) In phase In studies, surgery alone was not a control group in some reports. (2) The number of patients was too small to evaluate statistically. (3) Inter-institutional differences had important roles in the results of multicenter study in the other studies. For the future plans on adjuvant chemotherapy, it is important to make a simple designed protocol, and perform it as a multicenter study including institutions with minimum inter-institutional differences.
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