J.Jpn. Surg. Soc.. 96(4): 223-227, 1995

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Original article

A HISTPATHOLOGICAL STUDY ON POSTOPERATING RECURRENCE OF HEPATOCELLULAR CARCINOMA -AN EVALUATION BASED ON MULTIVARIATE ANALYSIS-

On postoperative recurrence of hepatocellular carcinoma (HCC), a multivariate analysis of Cox's regression model was conducted to determine the prognostic factors using histopathological findings of HCC and disease-free survival period. There were 105 males and 14 females (mean age±standard deviation : 56.1±8.2 yr) who had curative resection of HCC from 1979 to 1989. The histopathological findings were 11 factors as follows ; (1) diameter (2) number (3) histology (4) Edmondson classification (5) fc (6) fc-inf (7) sf (8) sf-inf (9) v (10) daughter nodule and (11) necrotic ration. From this analysis, among 11 histpathological parameters, only diameter of HCC (p=0.0029) was identified as a favorable independent prognostic predictor. Regarding to the tumor size with the hazard ratio, the tumor size of 4cm or less is seen to be the satisfactory means for assessing long-term disease-free survival of HCC.

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