J.Jpn. Surg. Soc.. 96(3): 168-173, 1995

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Original article

A CLINICO-PATHOLOGICAL STUDY ON PROGNOSIS IN NODE-NEGATIVE BREAST CANCER

In recent study, recurrence was seen in about 10% patients with node negative breast cancer during 10 years after operation. I evaluated prognostic factors including tumor diameter on the cut surface, histological infiltration diameter, histological malignancy, and expression of c-erbB-2 oncoprotein in 779 patients with node-negative breast cancer. The patient were operated from 1960 to 1972 at the Cancer Institute Hospital, Tokyo.
The overall survival rate in this series was 88.6% at ten years. The survival rate at ten years for patients with tumor more than 21mm in size was 82.6%, and for those with tumor more than 11mm in filtrated size was 83.1%. On the other hand, marked fatty tissue infiltration, marked lymphatic vessel invasion, extensive histological invasion and numerous mitosis were associated With poor prognosis. The expression of c-erbB-2 oncoprotein correlated with recurrence within 5 years.

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