J.Jpn. Surg. Soc.. 95(8): 485-495, 1994

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Original article

CHANGES IN THE PHAGOCYTIC CELL FUNCTIONS ELICITED BY SURGICAL INTERVENTION

To evaluate the feature of the phagocytic cell functions against surgical intervention, the author analyzed superoxide production and Mac-1 expression of peripheral polymorphonuclear leukocytes (PMN), cytokine production (IL-1 beta, TNFalpha) of peripheral monocyte (Mo) and peritoneal macrophage (Mφ) in 35 surgical patlents.
The ability of PMNs in superoxide anion production and the level of Mac-1 expression on PMNs increased within 24 hr after operation. Those changes synchronized that of Mo to produce IL-1 and TNF increased after operation and peaked at 1POD. And L-1 and TNF production of peritoneal MΦ increased and peaked at 8 hr after operation. However, both IL-1 and TNF could not be detected in their sera of all patients.
These findings disclosed that the surgical injury might induce in vivo activation of local MΦ and circulating Mo, and priming of the PMN by activated MΦ and due to their producing cytokines such as IL-1, TNF and G-CSF. It might be, therefore, concluded that these reactions of the phagocytic cells may be one of the host defense mechanisms against surgical injury.

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