J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 1523KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 95(6): 376-381, 1994

Original article

POSSIBLE INVOLVEMENT OF ACTIVATION OF PULMONARY MACROPHAGES IN RESPIRATORY FAILURE WITH ACUTE PANCREATITIS

First Department of Surgery, Kobe University School of Medicine, Kobe, Japan

Hiromu Haranomura, Yoshifumi Takeyama, Akihiro Toyokawa, Yoichi Saito

We examined the stimulatory state of pulmonary macrophages (Mφ) in rats with caerulein-induced pancreatitis by measuring their activity for free radical production in vitro and in situ using nitroblue tetrazolium (NBT) under treatment of phorbol myristate acetate.
The Mφ from bronchoalveolar lavage were significantly activated 24 h after caerulein administration. The lung perfusion with NBT in the presence of PMA confirmed in situ that pulmonary Mφ were also significantly activated in the same condition. Thereafter significant hypoxia was observed.
These results indicate that the activation of pulmonary Mφ may be involved in the respiratory failure in acute pancreatitis.

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