J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 459KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 95(5): 348-353, 1994

Original article

A CLINICAL STUDY OF RESPIRATORY COMPLICATION AFTER CARDIOPULMONARY BYPASS, WITH SPECIAL REFERENCE TO COMPLEMENT ACTIVATION, WBC AND GRANULOCYTE ELASTASE

1) Department of Cardiovascular Surgery, Yamagata Prefectural Central Hospital, Yamagata, Japan
2) Department of Thoracic and Cardiovascular Surgery, Tohoku University School of Medicine, Sendai, Japan

Susumu Nagamine1), Koichi Tabayashi2), Kiyoshi Haneda2), Hitoshi Mohri2)

Complement activation and it's influence on lung injury were studied in 20 patients undergoing cardio-pulmonary bypass (CPB). Anaphylatoxins increased remarkably to 3130±1770ng/ml in C3a, 2480±2530ng/ml in C4a and granulocytes were significantly fewer in left atrium (LA) than right atrium (RA) during CPB. Granulocyte elastase (GEL) was significantly higher in LA than RA at the time of reperfusion. Postoperative respiratory index was well corelated with C3a and GEL. We concluded that lung injury after CBP was caused by anaphylatoxin which aggregated granulocyte in pulmonary vesculature and released GEL during CPB, and anaphylatoxin was produced not only by using CBP but in patient's lung.

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