J.Jpn. Surg. Soc.. 95(5): 317-325, 1994
Original article
ANALYSIS OF GLUCOSE METABOLISM IN PATIENTS WITH ESOPHAGEAL CANCER BY PET: ESTIMATION OF HEXOKINASE ACTIVITY IN THE TUMOR AND USEFULNESS FOR CLINICAL ASSESSMENT USING 18F-FLUORODEOXYGLUCOSE
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Second Department of Surgery, Chiba University School of Medicine, Chiiba, Japan Toru Fukunaga, Kazuo Enomoto, Shinichi Okazumi, Toshiyuki Kikuchi, Hiroshi Yamamoto, Yoshio Koide, Kaichi Isono |
In 11 advanced cases k3 value renecting hexokinase activity and Ci/Cp ratio expressing FDG uptake were calculated from radloactivity in the tumor (Ci) and the plasma (Cp). Both k3 and Ci/Cp were well correlated with hexokinase activity from the resected specimen, so Ci/Cp was considered to be a convenient index for clinical assessment of esophageal cancer.
Forty-two cases before treatment revealed high accumulation of FDG, and 41 showed more than 2.0 of Ci/Cp. But, 10 normal controls and one esophageal benign tumor showed less than 2.0. As for 13 post-operative cases, 6 cases out of 7 with recurrence showed more than 2.0 for Ci/Cp, but all 6 cases of non-recurrent cases showed less than 2.0. FDG PET is an useful tool for differential diagnosis of recurrence.
The clinicopathological findings were investigated in 26 resected cases. ① Age, location, vertical extension, histologic feature, lymph node metastasis and histologic stage were not correlative with Ci/Cp. ② As for DNA ploidy pattern, aneuploidy group showed significently high Ci/Cp rather than diploidy group. ③ Eight cases which showed more than 5.0 of Ci/Cp resulted in poor prognoses compared with 14 cases which showed less than 5.0.
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